Tranexamic Acid Powder — Cosmetic Grade Skin-Brightening Active
Tranexamic Acid is a synthetic lysine derivative and cosmetic active ingredient (CAS 1197-18-8) best known for brightening skin tone and helping reduce melasma, dark spots and post-inflammatory hyperpigmentation (PIH). Jinan NorsonBio (济南诺森生物科技有限公司) supplies cosmetic-grade Tranexamic Acid powder at ≥ 99% purity by HPLC, backed by batch-level COA, TDS, SDS and complete technical documentation — with a 1 kg minimum order and reliable worldwide shipping for skincare brands, cosmetic formulators, OEM/ODM manufacturers and distributors.
What Is Tranexamic Acid?
Tranexamic Acid (also written TXA; synonyms AMCA, t-AMCHA; Chinese name 传明酸 / 氨甲环酸) is a water-soluble, white crystalline powder. Unlike tyrosinase inhibitors, it works mainly by blocking the plasminogen–plasmin signalling pathway that drives inflammation-linked pigmentation, and it also has a mild anti-inflammatory action. This dual mechanism is why formulators pair it with niacinamide, alpha-arbutin and vitamin C derivatives for multi-pathway brightening — while keeping the formula barrier-friendly for sensitive skin.
Key Features & Benefits
- High purity — ≥ 99.0% by HPLC, with impurity levels controlled to a tight reference standard (BP / EP / JP / ChP).
- Water-soluble & easy to formulate — freely soluble in water; add to the aqueous phase; cold processing is viable.
- Barrier-safe brightening — targets pigmentation while helping calm inflammation; ideal for sensitive-skin and post-procedure formulas.
- Formulation-friendly pH window — works well at pH 5.0–7.0 and is compatible with common brightening co-actives.
- Complete documentation — batch COA, TDS, SDS, TSE/BSE statement, allergen declaration and REACH/CPNP support documents.
- Flexible supply — from 1 kg samples to multi-ton contracts, with customizable specifications and packaging.
Applications
| Application Area | Typical Use |
|---|---|
| Brightening serums | 1%–3% TXA for daily tone-evening serums |
| Intensive spot treatments | 3%–5% for targeted dark-spot care |
| Creams & lotions | 1%–2% for everyday brightening moisturisers |
| Sheet masks | 0.5%–2% for rinse-off or leave-on masks |
| Eye care | 0.5%–1.5% targeting vascular dark circles |
| Post-procedure / aftercare | 1%–3% to reduce post-inflammatory rebound pigmentation |
| Body care | Brightening body lotions and hand creams |
| Oral care (selected markets) | Anti-inflammatory / hemostatic use in toothpaste |
Specifications
| Parameter | Specification |
|---|---|
| INCI Name | Tranexamic Acid |
| CAS No. | 1197-18-8 |
| Chemical Name | trans-4-(Aminomethyl)cyclohexanecarboxylic acid |
| Molecular Formula | C₈H₁₅NO₂ |
| Molecular Weight | 157.21 g/mol |
| EINECS / EC No. | 214-818-2 |
| Appearance | White or almost white crystalline powder |
| Assay (HPLC) | ≥ 99.0% |
| pH (5% aqueous solution) | 7.0 – 8.0 |
| Solubility | Freely soluble in water; practically insoluble in ethanol and oils |
| Heavy Metals | < 10 ppm |
| Arsenic | < 2 ppm |
| Loss on Drying | ≤ 0.5% |
| Sulphated Ash | ≤ 0.1% |
| Total Aerobic Count | ≤ 1000 CFU/g |
| Reference Standard | BP / EP / JP / ChP |
| Grade | Cosmetic Grade |
How to Use It in Your Formulation
- Recommended use level: 1%–3% for daily brightening products; up to 3%–5% for intensive spot treatments.
- pH: keep the final formula within pH 5.0–7.0 for best stability and efficacy.
- Processing: add to the aqueous phase; TXA dissolves at room temperature, so post-cooling addition (≤ 40 °C) is convenient.
- Do not co-formulate with pure L-ascorbic acid (it needs pH ≤ 3.5). Use a stable VC derivative instead.
- Proven partners: niacinamide (4%–5%) and alpha-arbutin (1%–2%) for a multi-pathway brightening framework.
Quality Assurance & Documentation
- Certificate of Analysis (COA) — batch-specific; HPLC purity, impurity profile, heavy metals, microbiology.
- Technical Data Sheet (TDS) — physicochemical properties, use levels, processing guidance.
- Safety Data Sheet (SDS) — GHS-compliant, current.
- Quality system documents — ISO 9001 or equivalent documentation from our qualified upstream production partner, available on request.
- REACH / CPNP support documents — for EU-bound shipments.
- TSE/BSE statement, allergen declaration and cruelty-free statement.
- Certificate of Origin (C/O) and other export documents.
Transparency note: Jinan NorsonBio is a professional supplier and global exporter of cosmetic ingredients, not a manufacturer. We source from qualified, audited upstream production partners, verify every batch with third-party testing, and stand behind the quality and documentation we deliver.
Packaging, Storage & Shipping
| Sample packing | 1 kg aluminum foil bag (double plastic inner bags), N.W. 1 kg |
| Bulk packing | 25 kg fiber drum with double plastic inner liners, N.W. 25 kg |
| Storage | Sealed, cool and dry place at room temperature (≤ 25 °C); protect from light and moisture |
| Shelf life | 2–3 years in unopened original packaging |
| Transport | Non-hazardous; shippable by courier, air or sea |
| Trade terms | FOB Qingdao / Shanghai, CIF, DDP |
| Lead time | Samples ~3–7 days; bulk typically 7–15 days after order confirmation |
| Courier | DHL / FedEx / UPS for samples; sea freight for bulk orders |
Why Buy From Jinan NorsonBio?
Jinan NorsonBio Co., Ltd. (济南诺森生物科技有限公司) is based in Jinan, Shandong, China — a major biotechnology and botanical-extract hub. As a supplier and exporter, we focus on the global sourcing, quality verification and distribution of high-quality cosmetic actives and plant extracts, working closely with qualified upstream production facilities.
- Quality verification — every batch supplied with ≥ 99% HPLC purity data and a batch COA aligned with BP/EP/JP/ChP reference standards.
- Complete documentation — COA, TDS, SDS, third-party test reports, TSE/BSE statements and REACH/CPNP support documents.
- Flexible supply — scale from 1 kg samples to multi-ton annual contracts; customizable specifications and packaging.
- Reliable multi-source sourcing — multiple qualified upstream partners protect you against supply interruption.
- Technical support — formulation guidance, stability consulting and regulatory registration support.
- Global logistics — FOB Qingdao/Shanghai, CIF and DDP terms; dependable delivery to North America, the EU, Southeast Asia, the Middle East and beyond.
Ready to source Tranexamic Acid Powder?
Request a free sample, current bulk pricing and our full technical dossier (COA / TDS / SDS).
Email: info@norsonbio.com | Web: www.norsonbio.com
Frequently Asked Questions
Q1. What is the recommended percentage of Tranexamic Acid in a formulation?
1%–3% for daily brightening products; 3%–5% for intensive spot treatments. Keep the final pH between 5.0 and 7.0. If you are new to TXA, start at 2%.
Q2. Can Tranexamic Acid be combined with niacinamide?
Yes — it is one of the best-documented brightening pairings. TXA 2%–3% + niacinamide 4%–5% + alpha-arbutin 1%–2% is a well-established multi-pathway framework that is stable at pH 5.0–5.5.
Q3. Is Tranexamic Acid irritating?
It is one of the gentlest brightening actives and is generally well tolerated, including by sensitive skin. A standard patch test is always recommended for new formulas.
Q4. Does it need heat to dissolve?
No. It is freely soluble in water at room temperature. Add it to the aqueous phase, ideally during the post-cooling stage (≤ 40 °C), to protect co-ingredients.
Q5. What is the difference between cosmetic-grade and pharmaceutical-grade?
The main difference is impurity control and intended use. Pharmaceutical grade must meet pharmacopoeia standards for injectable/oral use. Our cosmetic-grade powder is ≥ 99% pure by HPLC with impurity control aligned to a tight reference standard.
Q6. Can it be used during the day? Does it cause photosensitivity?
It is not photosensitising and is safe for daytime use. As with any brightening product, daily broad-spectrum SPF is recommended.
Q7. Do you provide REACH / CPNP documents?
Yes. We provide EU REACH registration support documents and the technical documents required for CPNP notification.
Q8. What is your MOQ, and how do I get a sample?
MOQ is 1 kg. We offer samples (100 g–1 kg) for laboratory evaluation, shipped via DHL/FedEx/UPS with typical delivery in 3–7 business days worldwide.
References & Further Reading
- Kim KM, Lim HW. The uses of tranexamic acid in dermatology: a review. Int J Dermatol. 2023;62(5):589-598.
- Gaćina K, Krstanović Ćosić A. The Use of Tranexamic Acid in Dermatology. Acta Clin Croat. 2023;62(2):368-372.
- da Silva Souza ID, Lampe L, Winn D. New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun-damaged skin. J Cosmet Dermatol. 2021;20(2):561-565.
- Zeng Y, Ma M, Chen Y, et al. Enhancing skin delivery of tranexamic acid via esterification. RSC Adv. 2024;14(47):34996-35004.
- Na JI, Choi SY, Yang SH, et al. Effect of tranexamic acid on melasma: a clinical trial with histological evaluation. J Eur Acad Dermatol Venereol. 2013;27:1035-1039.
- Maeda K, Naganuma M. Topical trans-4-aminomethylcyclohexanecarboxylic acid prevents ultraviolet radiation-induced pigmentation. J Photochem Photobiol B. 1998;47:136-141.
- Bala HR, Lee S, Wong C, et al. Oral tranexamic acid for the treatment of melasma: a review. Dermatol Surg. 2018;44:814-825.
- European Chemicals Agency (ECHA). Tranexamic Acid REACH Registration Dossier.
- U.S. Food and Drug Administration. Tranexamic Acid — Substance Registration System (TSCA Inventory, CAS 1197-18-8).
- GUINAMA Laboratories. Tranexamic Acid Technical Data Sheet (Ref: 10871), Version 4.0. Revised July 2024.
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